TRAPPC12

Across TCGA cell cohorts, TRAPPC12 mutation is significantly associated with the RNA expression of many other genes, with 480 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRAPPC12-associated genes across cancer lineages are COPS3, SLC25A32, and SSMEM1. Each is linked with TRAPPC12 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAPPC12-to-partner and partner-to-TRAPPC12 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, COPS3 grouped by TRAPPC12-low versus TRAPPC12-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAPPC12→partner) and Y-score (partner→TRAPPC12) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	COPS3 →	+0.515	+3.087	.004	.006	3	2
LARGE_INTESTINE	SLC25A32 →	+0.537	+3.237	<.001	.003	3	2
LARGE_INTESTINE	SSMEM1 →	+0.016	+1.707	.002	.006	3	2
LARGE_INTESTINE	PBK →	+0.937	+3.523	<.001	<.001	3	2
BLOOD_Leukemia	ZNF771 →	+0.908	+3.199	.001	.007	3	2
LARGE_INTESTINE	PTTG2 →	+0.061	+2.649	.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 480 associations by consensus.

COPS3 by TRAPPC12 expression — LARGE_INTESTINE

Explore this box plot interactively →