TRAPPC11

Across TCGA patient cohorts, TRAPPC11 mutation is significantly associated with the total protein of many other genes, with 40 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAPPC11-associated genes across cancer lineages are ASNS, Caspase-7-cleavedD198, and ATM. Each is linked with TRAPPC11 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRAPPC11-to-partner and partner-to-TRAPPC11 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TRAPPC11-low versus TRAPPC11-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAPPC11→partner) and Y-score (partner→TRAPPC11) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.298	+1.247	.006	.041	3	4
STAD	Caspase-7-cleavedD198 →	+1.501	+3.000	<.001	.036	3	3
UCEC	ATM →	-0.287	-1.794	.036	.024	3	3
UCEC	Cyclin-B1 →	+0.626	+2.415	<.001	.002	3	2
UCEC	mTOR_pS2448 →	-0.108	-1.664	.016	.019	3	2
UCEC	Notch1 →	+0.116	+1.598	.006	.019	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 40 associations by consensus.

ASNS by TRAPPC11 expression — UCEC

Explore this box plot interactively →