TRAPPC10

Across TCGA patient cohorts, TRAPPC10 mutation is significantly associated with the total protein of many other genes, with 38 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAPPC10-associated genes across cancer lineages are p38-MAPK_pT180_Y182, c-Kit, and FoxM1. Each is linked with TRAPPC10 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRAPPC10-to-partner and partner-to-TRAPPC10 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, p38-MAPK_pT180_Y182 grouped by TRAPPC10-low versus TRAPPC10-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAPPC10→partner) and Y-score (partner→TRAPPC10) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	p38-MAPK_pT180_Y182 →	-0.358	-1.662	.010	.010	3	3
UCEC	c-Kit →	-0.161	-1.643	.026	.003	3	3
STAD	FoxM1 →	+0.440	+2.838	.002	.033	3	2
UCEC	EGFR_pY1068 →	-0.222	-2.247	.004	.001	3	2
UCEC	Ku80 →	+0.179	+1.214	.014	.018	3	2
UCEC	Notch1 →	+0.222	+2.169	<.001	<.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 38 associations by consensus.

p38-MAPK_pT180_Y182 by TRAPPC10 expression — UCEC

Explore this box plot interactively →