TRANK1

Across TCGA pan-cancer cohorts, TRANK1 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TRANK1 data layer compared with 25 for mass-spec protein and 9 for mutation status.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where higher TRANK1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TRANK1 expression acts as an unfavorable survival marker, although some lineages such as HNSC and CCRCC show a favorable association.

HNSC, CCRCC, and LUAD are the cancer types where TRANK1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
HNSC	OS	Quartile	IV	0.932	0.588	.018	26	view →
CCRCC	DFS	Median	All	0.903	0.337	.002	10	view →
LUAD	DFS	Tertile	All	0.739	0.467	.016	10	view →
PDAC	DFS	Tertile	III,IV	0.306	0.785	.003	8	view →
GBM	DFS	Median	All	0.247	0.471	.020	2	view →
LSCC	DFS	Quartile	All	1.000	0.437	.026	1	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TRANK1–HNSC (OS)

Open the HNSC breakdown →