TRANK1

Across TCGA patient cohorts, TRANK1 mutation is significantly associated with the total protein of many other genes, with 100 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRANK1-associated genes across cancer lineages are Cyclin-B1, C-Raf, and NF2. Each is linked with TRANK1 in more than 5 cancer types. Because this analysis shows association rather than direction, both TRANK1-to-partner and partner-to-TRANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Cyclin-B1 grouped by TRANK1-low versus TRANK1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRANK1→partner) and Y-score (partner→TRANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Cyclin-B1 →	+0.467	+2.070	<.001	.001	3	6
STAD	C-Raf →	+0.222	+2.584	<.001	.010	3	4
BLCA	NF2 →	+0.176	+2.807	.025	.003	3	3
BLCA	p21 →	+0.380	+2.584	.024	.010	3	3
BLCA	Chk2_pT68 →	-0.172	-2.807	.004	.003	3	3
STAD	PCNA →	+0.331	+3.169	.006	.018	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 100 associations by consensus.

Cyclin-B1 by TRANK1 expression — UCEC

Explore this box plot interactively →