TRANK1

Across TCGA cell cohorts, TRANK1 mutation is significantly associated with the RNA expression of many other genes, with 1,159 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRANK1-associated genes across cancer lineages are GIMD1, PRDM7, and AOC2. Each is linked with TRANK1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRANK1-to-partner and partner-to-TRANK1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GIMD1 grouped by TRANK1-low versus TRANK1-high in OESOPHAGUS.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRANK1→partner) and Y-score (partner→TRANK1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
OESOPHAGUS	GIMD1 →	+0.055	+4.115	<.001	.001	3	3
OVARY	PRDM7 →	+0.095	+3.362	.001	.005	3	3
LARGE_INTESTINE	AOC2 →	+0.495	+3.321	.005	.003	3	3
LARGE_INTESTINE	KSR2 →	+0.453	+3.234	<.001	.004	3	3
LARGE_INTESTINE	ZNF280B →	+0.600	+2.743	<.001	.001	3	3
URINARY_TRACT	PRDM14 →	+0.011	+4.217	.002	.005	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,159 associations by consensus.

GIMD1 by TRANK1 expression — OESOPHAGUS

Explore this box plot interactively →