TRAM2

Across TCGA patient cohorts, TRAM2 mutation is significantly associated with the total protein of many other genes, with 34 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAM2-associated genes across cancer lineages are Src_pY527, EGFR_pY1068, and eIF4E. Each is linked with TRAM2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAM2-to-partner and partner-to-TRAM2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Src_pY527 grouped by TRAM2-low versus TRAM2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAM2→partner) and Y-score (partner→TRAM2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Src_pY527 →	-0.498	-2.690	.002	.006	3	2
UCEC	EGFR_pY1068 →	-0.259	-2.222	.005	.009	3	1
UCEC	eIF4E →	+0.186	+2.115	.018	.017	3	1
UCEC	ERK2 →	+0.169	+1.700	.019	.042	3	1
UCEC	FASN →	+0.339	+2.584	.021	.010	3	1
UCEC	FOXO3a_pS318_S321 →	-0.105	-2.212	.024	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 34 associations by consensus.

Src_pY527 by TRAM2 expression — UCEC

Explore this box plot interactively →