TRAM1L1

Across TCGA patient cohorts, TRAM1L1 mutation is significantly associated with the RNA expression of many other genes, with 2,562 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAM1L1-associated genes across cancer lineages are VN1R5, RNU6-598P, and MIR4698. Each is linked with TRAM1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAM1L1-to-partner and partner-to-TRAM1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VN1R5 grouped by TRAM1L1-low versus TRAM1L1-high in BLCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAM1L1→partner) and Y-score (partner→TRAM1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLCA	VN1R5 →	+0.214	+3.816	<.001	.005	3	2
BLCA	RNU6-598P →	+0.265	+3.376	<.001	.007	3	2
UCEC	MIR4698 →	+0.305	+2.093	<.001	.004	3	2
UCEC	NOL12 →	+0.394	+1.970	<.001	<.001	3	2
HNSC	OR4K5 →	+0.032	+4.327	<.001	.009	3	2
HNSC	RNA5SP35 →	+0.289	+4.266	.002	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,562 associations by consensus.

VN1R5 by TRAM1L1 expression — BLCA

Explore this box plot interactively →