TRAM1L1

Across TCGA patient cohorts, TRAM1L1 mutation is significantly associated with the total protein of many other genes, with 36 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAM1L1-associated genes across cancer lineages are ATM, PCNA, and ASNS. Each is linked with TRAM1L1 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRAM1L1-to-partner and partner-to-TRAM1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ATM grouped by TRAM1L1-low versus TRAM1L1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAM1L1→partner) and Y-score (partner→TRAM1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ATM →	-0.402	-1.700	.010	.042	3	3
UCEC	PCNA →	+0.208	+2.000	.005	.009	3	2
UCEC	ASNS →	+0.365	+1.906	.003	.015	3	2
UCEC	Bax →	+0.212	+3.807	.010	<.001	3	2
UCEC	4E-BP1 →	+0.351	+3.700	<.001	.001	3	2
UCEC	EGFR_pY1068 →	-0.260	-3.087	.002	<.001	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 36 associations by consensus.

ATM by TRAM1L1 expression — UCEC

Explore this box plot interactively →