TRAM1L1

Across TCGA cell cohorts, TRAM1L1 mutation is significantly associated with the RNA expression of many other genes, with 18 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRAM1L1-associated genes across cancer lineages are LGALS12, G6PC2, and SYNPR. Each is linked with TRAM1L1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAM1L1-to-partner and partner-to-TRAM1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LGALS12 grouped by TRAM1L1-low versus TRAM1L1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAM1L1→partner) and Y-score (partner→TRAM1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	LGALS12 →	+0.122	+3.898	<.001	.005	3	1
LARGE_INTESTINE	G6PC2 →	+0.030	+3.921	.001	.001	3	1
LARGE_INTESTINE	SYNPR →	+0.627	+3.520	.008	.005	3	1
LARGE_INTESTINE	DNASE1L3 →	+0.111	+3.754	<.001	.002	3	1
LARGE_INTESTINE	TBC1D21 →	+0.008	+3.700	<.001	.009	3	1
LARGE_INTESTINE	FAM71B →	+0.002	+3.700	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

LGALS12 by TRAM1L1 expression — LARGE_INTESTINE

Explore this box plot interactively →