TRAM1L1

Across TCGA cell cohorts, TRAM1L1 mutation is significantly associated with the mutation status of many other genes, with 3,988 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRAM1L1-associated genes across cancer lineages are SCRIB, CACNA1H, and LYST. Each is linked with TRAM1L1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRAM1L1-to-partner and partner-to-TRAM1L1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SCRIB grouped by TRAM1L1-low versus TRAM1L1-high in STOMACH.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAM1L1→partner) and Y-score (partner→TRAM1L1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STOMACH	SCRIB →	+2.415	+3.807	.006	.006	1	4
BLOOD_Leukemia	CACNA1H →	+2.101	+3.899	.007	.007	1	4
STOMACH	LYST →	+3.584	+3.584	.006	.006	1	4
BLOOD_Leukemia	ABCA5 →	+3.145	+3.932	.004	.004	1	4
STOMACH	TAF1 →	+3.584	+3.584	.006	.006	1	4
LUNG_SCLC	TRIO →	+3.137	+4.608	.001	.001	1	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,988 associations by consensus.

SCRIB by TRAM1L1 expression — STOMACH

Explore this box plot interactively →