TRAM1

Across TCGA patient cohorts, TRAM1 mutation is significantly associated with the total protein of many other genes, with 19 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAM1-associated genes across cancer lineages are ASNS, eIF4G, and ACC1. Each is linked with TRAM1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAM1-to-partner and partner-to-TRAM1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, ASNS grouped by TRAM1-low versus TRAM1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAM1→partner) and Y-score (partner→TRAM1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	ASNS →	+0.473	+2.700	<.001	.006	3	2
UCEC	eIF4G →	+0.245	+2.999	.044	.035	3	1
UCEC	ACC1 →	+0.289	+2.183	.042	.033	3	1
UCEC	Ku80 →	+0.195	+1.598	.035	.022	3	1
UCEC	p62 Lck ligand →	+0.473	+3.459	<.001	.005	3	1
UCEC	PCNA →	+0.216	+2.321	.011	.033	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 19 associations by consensus.

ASNS by TRAM1 expression — UCEC

Explore this box plot interactively →