Across TCGA pan-cancer cohorts, TRAJ5 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRAJ5’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAJ5 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAJ5 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

KIRC, BRCA, and STAD are the cancer types where TRAJ5 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAJ5 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+0.550	<.001	9	view →
BRCA	All	All	+0.300	.003	4	view →
STAD	All	All	+0.523	.003	3	view →
LUSC	Male	III,IV	−0.679	.024	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TRAJ5 RNA expression & survival · all TRAJ5 data types