Across TCGA pan-cancer cohorts, TRAJ49 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TRAJ49’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where TRAJ49 RNA is repressed in tumor relative to normal tissue. In most cancer types TRAJ49 is over-expressed in tumor, although a few such as COAD and READ show the opposite, repressed pattern.

COAD, READ, and KIRC are the cancer types where TRAJ49 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAJ49 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	All	IV	−1.381	.002	5	view →
READ	All	II,III,IV	−1.347	<.001	5	view →
KIRC	Male	IV	+0.468	.001	4	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TRAJ49 RNA expression & survival · all TRAJ49 data types