Across TCGA pan-cancer cohorts, TRAJ40 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TRAJ40’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAJ40 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAJ40 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

KIRC, BRCA, and LUSC are the cancer types where TRAJ40 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAJ40 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.233	<.001	8	view →
BRCA	Female	All	+0.243	.005	4	view →
LUSC	Male	III,IV	−0.882	.033	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TRAJ40 RNA expression & survival · all TRAJ40 data types