Across TCGA pan-cancer cohorts, TRAJ27 RNA differs between tumor and matched normal tissue in 3 of 18 cancer types tested, making tumor–normal expression one of TRAJ27’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where TRAJ27 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAJ27 is over-expressed in tumor, although a few such as KIRP show the opposite, repressed pattern.

BRCA, KICH, and KIRP are the cancer types where TRAJ27 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAJ27 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	Female	All	+0.352	.002	4	view →
KICH	All	All	+0.540	.010	2	view →
KIRP	All	All	−0.242	.005	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 3 strongest of 3 lineages.

Exploration

Same gene, other analysis: TRAJ27 RNA expression & survival · all TRAJ27 data types