Across TCGA pan-cancer cohorts, TRAJ23 RNA is linked to patient survival in 15 of 34 cancer types, making it the most broadly survival-associated TRAJ23 data layer compared with 2 for mutation status.
The strongest signal is observed in cholangiocarcinoma (CHOL), where higher TRAJ23 RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRAJ23 expression acts as an unfavorable survival marker, although some lineages such as SKCM and CESC show a favorable association.
CHOL, SKCM, and CESC are the cancer types where TRAJ23 RNA most reproducibly stratifies survival.
RNA survival associations by lineage
Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.