Across TCGA pan-cancer cohorts, TRAJ23 Mutation is linked to patient survival in 2 of 34 cancer types, making it a survival-associated TRAJ23 data layer compared with 15 for mass-spec protein.

The strongest signal is observed in skin cutaneous melanoma (SKCM), where higher TRAJ23 Mutation is associated with worse disease-free survival. In most high-consensus cancer types, elevated TRAJ23 expression acts as an unfavorable survival marker.

SKCM and HNSC are the cancer types where TRAJ23 Mutation most reproducibly stratifies survival.

Mutation survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
SKCM	DFS	Median	II,III,IV	0.121	0.693	<.001	31	view →
HNSC	OS	Median	All	0.099	0.768	<.001	12	view →

Pink = unfavorable, green = favorable. Showing the 2 strongest of 2 lineages.

Exploration

Same gene, other analysis: TRAJ23 tumor-vs-normal RNA expression · all TRAJ23 data types