Across TCGA pan-cancer cohorts, TRAJ21 RNA differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRAJ21’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAJ21 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAJ21 is over-expressed in tumor, although a few such as LUSC show the opposite, repressed pattern.

KIRC, LUSC, and STAD are the cancer types where TRAJ21 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAJ21 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	II,III,IV	+0.112	.011	5	view →
LUSC	All	III,IV	−1.133	.012	2	view →
STAD	Female	All	+1.022	.036	2	view →
LUAD	All	All	+0.371	.041	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

Exploration

Same gene, other analysis: TRAJ21 RNA expression & survival · all TRAJ21 data types