Across TCGA pan-cancer cohorts, TRAJ16 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TRAJ16’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAJ16 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAJ16 is over-expressed in tumor, although a few such as COAD and THCA show the opposite, repressed pattern.

KIRC, BRCA, and HNSC are the cancer types where TRAJ16 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAJ16 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	+0.281	<.001	4	view →
BRCA	Female	All	+0.216	.024	4	view →
HNSC	Female	III,IV	+0.597	.039	2	view →
COAD	Female	All	−0.220	.016	2	view →
THCA	Female	All	−0.275	.043	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TRAJ16 RNA expression & survival · all TRAJ16 data types