Across TCGA pan-cancer cohorts, TRAJ14 RNA differs between tumor and matched normal tissue in 1 of 18 cancer types tested, making tumor–normal expression one of TRAJ14’s most consistent transcriptional readouts.
The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where TRAJ14 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAJ14 is over-expressed in tumor.
KIRC are the cancer types where TRAJ14 tumor–normal differential expression is most reproducible.