TRAFD1

Across TCGA cell cohorts, TRAFD1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,556 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TRAFD1-associated GO terms across cancer lineages are Regulation of mRNA processing, Regulation of mRNA splicing, via spliceosome, and mRNA splice site recognition. Each is linked with TRAFD1 in more than 14 cancer types. Because this analysis shows association rather than direction, both TRAFD1-to-partner and partner-to-TRAFD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of mRNA processing grouped by TRAFD1-low versus TRAFD1-high in LARGE_INTESTINE.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAFD1→partner) and Y-score (partner→TRAFD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	Regulation of mRNA processing →	+0.074	+0.883	<.001	<.001	3	15
BLOOD_Lymphoma	Regulation of mRNA splicing, via spliceosome →	+0.074	+0.965	<.001	.002	3	14
BLOOD_Lymphoma	mRNA splice site recognition →	+0.112	+1.194	<.001	<.001	3	13
BREAST	Regulation of syncytium formation by plasma membrane fusion →	+0.084	+1.006	.003	.001	3	13
STOMACH	Process utilizing autophagic mechanism →	+0.083	+1.101	.001	<.001	3	13
STOMACH	Autophagy →	+0.083	+1.101	.001	<.001	3	13

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,556 associations by consensus.

Regulation of mRNA processing by TRAFD1 expression — LARGE_INTESTINE

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