TRAFD1

Across TCGA cell cohorts, TRAFD1 mutation is significantly associated with the RNA expression of many other genes, with 42 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRAFD1-associated genes across cancer lineages are TSPY3, C1orf232, and EPPIN. Each is linked with TRAFD1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAFD1-to-partner and partner-to-TRAFD1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, TSPY3 grouped by TRAFD1-low versus TRAFD1-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAFD1→partner) and Y-score (partner→TRAFD1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	TSPY3 →	+0.626	+4.736	<.001	.009	3	1
UPPER_AERODIGESTIVE_TRACT	C1orf232 →	+0.084	+4.736	<.001	.009	3	1
BLOOD_Leukemia	EPPIN →	+0.006	+4.922	.005	.009	3	1
BLOOD_Leukemia	NKX2-6 →	+0.639	+5.201	<.001	.006	3	1
BLOOD_Leukemia	OR52E4 →	+0.012	+5.201	.008	.006	3	1
BLOOD_Leukemia	OC90 →	+0.013	+5.201	<.001	.006	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 42 associations by consensus.

TSPY3 by TRAFD1 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →