TRAF7

Across TCGA pan-cancer cohorts, TRAF7 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of TRAF7’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where TRAF7 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types TRAF7 is over-expressed in tumor.

HNSC, LUAD, and KIRP are the cancer types where TRAF7 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAF7 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	All	+1.017	<.001	12	view →
LUAD	Male	III,IV	+1.045	<.001	11	view →
KIRP	Male	II,III,IV	+0.931	<.001	11	view →
COAD	Male	III,IV	+0.742	<.001	10	view →
LIHC	Female	II,III,IV	+1.422	<.001	9	view →
LUSC	Female	All	+1.412	<.001	8	view →
BRCA	All	III,IV	+0.814	<.001	6	view →
UCEC	All	III,IV	+0.735	.003	6	view →
CHOL	All	All	+2.208	<.001	5	view →
STAD	All	II,III,IV	+0.771	<.001	5	view →
BLCA	All	All	+0.428	.007	3	view →
PRAD	All	All	+0.478	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

TRAF7–HNSC

Open the HNSC breakdown →