Across TCGA pan-cancer cohorts, TRAF6P1 RNA differs between tumor and matched normal tissue in 5 of 18 cancer types tested, making tumor–normal expression one of TRAF6P1’s most consistent transcriptional readouts.

The strongest signal is observed in breast invasive carcinoma (BRCA), where TRAF6P1 RNA is repressed in tumor relative to normal tissue. In most cancer types TRAF6P1 is over-expressed in tumor, although a few such as BRCA and KICH show the opposite, repressed pattern.

BRCA, KICH, and READ are the cancer types where TRAF6P1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAF6P1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BRCA	All	II,III,IV	−0.013	.004	6	view →
KICH	Male	All	−0.151	.002	3	view →
READ	All	All	+0.037	.033	2	view →
LUAD	All	All	+0.017	.013	1	view →
HNSC	All	All	+0.008	.031	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 5 strongest of 5 lineages.

Exploration

Same gene, other analysis: TRAF6P1 RNA expression & survival · all TRAF6P1 data types