TRAF6

Across TCGA patient cohorts, TRAF6 protein abundance is significantly associated with the RNA expression of many other genes, with 6,189 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible TRAF6-associated genes across cancer lineages are FBXO3, RNF141, and TCP11L1. Each is linked with TRAF6 in more than 4 cancer types. Because this analysis shows association rather than direction, both TRAF6-to-partner and partner-to-TRAF6 results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, TRAF6 versus FBXO3 in GBM, with a Pearson correlation of 0.42.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF6→partner) and Y-score (partner→TRAF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	FBXO3 →	+0.426	+0.340	<.001	<.001	3	5
LUAD	RNF141 →	+0.477	+0.181	<.001	<.001	3	4
COAD	TCP11L1 →	+0.402	+0.238	.002	<.001	3	4
UCEC	JAM2 →	+0.814	+0.177	.002	.001	3	4
COAD	PI16 →	+0.875	+0.202	.007	.001	3	4
LSCC	RAG1 →	+1.035	+0.232	<.001	<.001	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,189 associations by consensus.

TRAF6 vs FBXO3 — GBM

Explore this scatter interactively →