TRAF6

Across TCGA patient cohorts, TRAF6 mutation is significantly associated with the total protein of many other genes, with 25 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAF6-associated genes across cancer lineages are Gab2, C-Raf, and EGFR_pY1068. Each is linked with TRAF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF6-to-partner and partner-to-TRAF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by TRAF6-low versus TRAF6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF6→partner) and Y-score (partner→TRAF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.304	+1.678	.026	.023	3	2
UCEC	C-Raf →	+0.205	+2.000	<.001	.030	3	2
UCEC	EGFR_pY1068 →	-0.300	-2.584	.001	.001	3	1
UCEC	eIF4E →	+0.160	+3.013	.047	.018	3	1
UCEC	FoxM1 →	+0.220	+2.009	.026	.017	3	1
UCEC	JNK_pT183_Y185 →	-0.134	-2.115	.038	.017	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

Gab2 by TRAF6 expression — UCEC

Explore this box plot interactively →