TRAF6

Across TCGA cell cohorts, TRAF6 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,441 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRAF6-associated GO terms across cancer lineages are Interleukin-17A-mediated signaling pathway, Endosomal transport, and Regulation of protein K48-linked ubiquitination. Each is linked with TRAF6 in more than 14 cancer types. Because this analysis shows association rather than direction, both TRAF6-to-partner and partner-to-TRAF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Interleukin-17A-mediated signaling pathway grouped by TRAF6-low versus TRAF6-high in KIDNEY.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF6→partner) and Y-score (partner→TRAF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
KIDNEY	Interleukin-17A-mediated signaling pathway →	+0.102	+0.732	<.001	.001	3	15
BREAST	Endosomal transport →	+0.056	+0.589	<.001	.003	3	14
BREAST	Regulation of protein K48-linked ubiquitination →	+0.157	+0.761	<.001	<.001	3	14
OVARY	Post-Golgi vesicle-mediated transport →	+0.059	+0.526	<.001	.001	3	14
BREAST	Vacuolar transport →	+0.059	+0.599	.001	<.001	3	14
UPPER_AERODIGESTIVE_TRACT	Macroautophagy →	+0.054	+0.602	.004	.007	2	14

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,441 associations by consensus.

Interleukin-17A-mediated signaling pathway by TRAF6 expression — KIDNEY

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