TRAF6

Across TCGA cell cohorts, TRAF6 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRAF6-associated genes across cancer lineages are CABP5, NTSR2, and PYDC2. Each is linked with TRAF6 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF6-to-partner and partner-to-TRAF6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CABP5 grouped by TRAF6-low versus TRAF6-high in BLOOD_Lymphoma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF6→partner) and Y-score (partner→TRAF6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Lymphoma	CABP5 →	+0.016	+4.867	<.001	.009	3	1
BLOOD_Lymphoma	NTSR2 →	+0.569	+5.209	<.001	.005	3	1
BLOOD_Lymphoma	PYDC2 →	+0.146	+6.247	<.001	<.001	3	1
BLOOD_Leukemia	OPRM1 →	+0.025	+5.201	<.001	.006	3	1
BLOOD_Leukemia	FAM9A →	+0.019	+5.539	<.001	.003	3	1
BLOOD_Leukemia	FAM47A →	+0.041	+4.922	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

CABP5 by TRAF6 expression — BLOOD_Lymphoma

Explore this box plot interactively →