TRAF5

Across TCGA pan-cancer cohorts, TRAF5 mass-spec protein is linked to patient survival in 6 of 34 cancer types, making it a survival-associated TRAF5 data layer compared with 21 for mass-spec protein and 3 for mutation status.

The strongest signal is observed in uterine corpus endometrial carcinoma (UCEC), where higher TRAF5 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TRAF5 expression acts as an unfavorable survival marker, although some lineages such as UCEC and PDAC show a favorable association.

UCEC, LSCC, and PDAC are the cancer types where TRAF5 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
UCEC	DFS	Tertile	All	0.940	0.712	.006	32	view →
LSCC	DFS	Tertile	All	0.587	0.836	.016	14	view →
PDAC	OS	Tertile	III,IV	0.830	0.330	.008	13	view →
COAD	DFS	Median	IV	0.565	1.000	.028	6	view →
CCRCC	DFS	Quartile	II,III,IV	0.321	0.842	.031	6	view →
GBM	OS	Quartile	All	0.606	0.347	.044	2	view →

Pink = unfavorable, green = favorable. Showing the 6 strongest of 6 lineages.

TRAF5–UCEC (DFS)

Open the UCEC breakdown →