TRAF5

Across TCGA pan-cancer cohorts, TRAF5 mass-spec protein differs between tumor and matched normal tissue in 4 of 18 cancer types tested, making tumor–normal expression one of TRAF5’s most consistent transcriptional readouts.

The strongest signal is observed in lung adenocarcinoma (LUAD), where TRAF5 mass-spec protein is more highly expressed in tumor relative to normal tissue. In most cancer types TRAF5 is over-expressed in tumor, although a few such as PDAC show the opposite, repressed pattern.

LUAD, PDAC, and LSCC are the cancer types where TRAF5 tumor–normal differential expression is most reproducible.

mass-spec protein tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in TRAF5 mass-spec protein (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
LUAD	Male	All	+0.336	<.001	7	view →
PDAC	All	All	−0.284	<.001	5	view →
LSCC	All	All	+0.099	.012	2	view →
CCRCC	All	All	+0.230	.023	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 4 strongest of 4 lineages.

TRAF5–LUAD

Open the LUAD breakdown →