TRAF5

Across TCGA patient cohorts, TRAF5 mutation is significantly associated with the RNA expression of many other genes, with 2,301 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAF5-associated genes across cancer lineages are VCY, CRYZL1, and SS18L2P1. Each is linked with TRAF5 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF5-to-partner and partner-to-TRAF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, VCY grouped by TRAF5-low versus TRAF5-high in BRCA.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF5→partner) and Y-score (partner→TRAF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	VCY →	+0.089	+8.471	<.001	.005	3	2
UCEC	CRYZL1 →	+0.413	+3.502	<.001	<.001	3	2
COAD	SS18L2P1 →	+0.481	+2.695	<.001	.004	3	2
COAD	H2AC4 →	+1.090	+3.335	<.001	.005	3	2
COAD	WDR7 →	+0.401	+3.429	.007	.004	3	2
UCEC	SUSD2P2 →	+0.259	+1.905	.003	.001	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,301 associations by consensus.

VCY by TRAF5 expression — BRCA

Explore this box plot interactively →