TRAF5

Across TCGA patient cohorts, TRAF5 mutation is significantly associated with the total protein of many other genes, with 41 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAF5-associated genes across cancer lineages are STAT3_pY705, TSC1, and MEK1. Each is linked with TRAF5 in more than 2 cancer types. Because this analysis shows association rather than direction, both TRAF5-to-partner and partner-to-TRAF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, STAT3_pY705 grouped by TRAF5-low versus TRAF5-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF5→partner) and Y-score (partner→TRAF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	STAT3_pY705 →	-0.472	-2.212	<.001	.010	3	3
COAD	TSC1 →	-0.495	-3.161	<.001	.019	3	2
UCEC	MEK1 →	+0.451	+2.584	.002	.010	3	2
UCEC	Akt_pT308 →	+0.520	+2.999	.040	.035	3	2
UCEC	PCNA →	+0.272	+3.584	.001	.002	3	2
UCEC	Axl →	-0.185	-2.285	.030	.006	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 41 associations by consensus.

STAT3_pY705 by TRAF5 expression — UCEC

Explore this box plot interactively →