TRAF5

Across TCGA cell cohorts, TRAF5 RNA expression is significantly associated with the go_rna of many other GO terms, with 3,707 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRAF5-associated GO terms across cancer lineages are DNA biosynthetic process, Mismatch repair, and Chiasma assembly. Each is linked with TRAF5 in more than 10 cancer types. Because this analysis shows association rather than direction, both TRAF5-to-partner and partner-to-TRAF5 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DNA biosynthetic process grouped by TRAF5-low versus TRAF5-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF5→partner) and Y-score (partner→TRAF5) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	DNA biosynthetic process →	+0.065	+0.905	<.001	<.001	3	11
UPPER_AERODIGESTIVE_TRACT	Mismatch repair →	+0.092	+1.022	<.001	<.001	3	10
LARGE_INTESTINE	Chiasma assembly →	+0.201	+1.178	<.001	.005	3	10
UPPER_AERODIGESTIVE_TRACT	Intraciliary transport →	+0.064	+1.540	.007	<.001	3	9
BREAST	Subtelomeric heterochromatin formation →	+0.092	+1.625	.001	.002	3	9
OESOPHAGUS	Protein localization to cytoplasmic stress granule →	+0.159	+1.228	.001	.003	2	9

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,707 associations by consensus.

DNA biosynthetic process by TRAF5 expression — SKIN

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