TRAF4

Across TCGA pan-cancer cohorts, TRAF4 mass-spec protein is linked to patient survival in 4 of 34 cancer types, making it a survival-associated TRAF4 data layer compared with 24 for mass-spec protein.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TRAF4 mass-spec protein is associated with better disease-free survival. In most high-consensus cancer types, elevated TRAF4 expression acts as an unfavorable survival marker, although some lineages such as PDAC and UCEC show a favorable association.

PDAC, UCEC, and HNSC are the cancer types where TRAF4 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	DFS	Tertile	III,IV	0.875	0.175	.006	14	view →
UCEC	DFS	Tertile	II,III,IV	0.904	0.475	.036	8	view →
HNSC	OS	Median	II,III,IV	0.819	0.616	.016	5	view →
GBM	OS	Tertile	All	0.924	0.741	.011	4	view →

Pink = unfavorable, green = favorable. Showing the 4 strongest of 4 lineages.

TRAF4–PDAC (DFS)

Open the PDAC breakdown →