TRAF4

Across TCGA patient cohorts, TRAF4 mutation is significantly associated with the RNA expression of many other genes, with 476 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAF4-associated genes across cancer lineages are IL21, MIR3162, and RNU6-97P. Each is linked with TRAF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF4-to-partner and partner-to-TRAF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, IL21 grouped by TRAF4-low versus TRAF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF4→partner) and Y-score (partner→TRAF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	IL21 →	+0.156	+2.442	<.001	.001	3	2
CESC	MIR3162 →	+0.635	+5.103	<.001	.008	3	2
COAD	RNU6-97P →	+0.678	+3.951	.002	.003	3	2
UCEC	CCDC163 →	+0.576	+3.337	.001	.005	3	1
CESC	RNA5SP294 →	+0.409	+5.103	<.001	.008	3	1
LGG	AMY1C →	+0.024	+7.977	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 476 associations by consensus.

IL21 by TRAF4 expression — UCEC

Explore this box plot interactively →