TRAF4

Across TCGA patient cohorts, TRAF4 mutation is significantly associated with the total protein of many other genes, with 20 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAF4-associated genes across cancer lineages are Gab2, JNK_pT183_Y185, and JNK2. Each is linked with TRAF4 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF4-to-partner and partner-to-TRAF4 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by TRAF4-low versus TRAF4-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF4→partner) and Y-score (partner→TRAF4) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.474	+2.321	.008	.035	3	1
UCEC	JNK_pT183_Y185 →	-0.298	-3.321	<.001	.010	3	1
UCEC	JNK2 →	+0.213	+2.321	.032	.035	3	1
UCEC	Ku80 →	+0.264	+3.472	.025	.002	3	1
UCEC	NDRG1_pT346 →	-0.506	-3.000	.039	.036	3	1
UCEC	Notch1 →	+0.237	+2.331	<.001	.019	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 20 associations by consensus.

Gab2 by TRAF4 expression — UCEC

Explore this box plot interactively →