TRAF3IP2

Across TCGA patient cohorts, TRAF3IP2 mutation is significantly associated with the RNA expression of many other genes, with 1,067 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAF3IP2-associated genes across cancer lineages are RNU6-774P, RPL22P5, and PPP2R1B. Each is linked with TRAF3IP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF3IP2-to-partner and partner-to-TRAF3IP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNU6-774P grouped by TRAF3IP2-low versus TRAF3IP2-high in HNSC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF3IP2→partner) and Y-score (partner→TRAF3IP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	RNU6-774P →	+0.385	+5.655	<.001	.004	3	2
HNSC	RPL22P5 →	+0.121	+5.124	<.001	.008	3	2
BLCA	PPP2R1B →	+0.483	+3.198	.008	.009	3	2
BLCA	MTA2 →	+0.372	+3.374	.009	.004	3	2
BLCA	LGR4 →	+0.905	+3.466	.005	.002	3	2
UCEC	H4C12 →	+0.651	+2.779	<.001	.002	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,067 associations by consensus.

RNU6-774P by TRAF3IP2 expression — HNSC

Explore this box plot interactively →