TRAF3IP2

Across TCGA patient cohorts, TRAF3IP2 mutation is significantly associated with the total protein of many other genes, with 24 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAF3IP2-associated genes across cancer lineages are PDCD4, EGFR_pY1068, and FASN. Each is linked with TRAF3IP2 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF3IP2-to-partner and partner-to-TRAF3IP2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PDCD4 grouped by TRAF3IP2-low versus TRAF3IP2-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF3IP2→partner) and Y-score (partner→TRAF3IP2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PDCD4 →	-0.604	-3.169	.001	.018	3	2
UCEC	EGFR_pY1068 →	-0.285	-2.321	.005	.006	3	1
UCEC	FASN →	+0.417	+1.807	.010	.027	3	1
UCEC	FOXO3a_pS318_S321 →	-0.121	-3.000	.019	.001	3	1
UCEC	ACC_pS79 →	+0.340	+1.807	.017	.027	3	1
UCEC	GAPDH →	+0.596	+2.459	.007	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 24 associations by consensus.

PDCD4 by TRAF3IP2 expression — UCEC

Explore this box plot interactively →