Across TCGA cell cohorts, TRAF3IP1 mutation is significantly associated with the RNA expression of many other genes, with 10 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRAF3IP1-associated genes across cancer lineages are MSGN1, ADAM7, and WFDC8. Each is linked with TRAF3IP1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF3IP1-to-partner and partner-to-TRAF3IP1 results are reported.

Each partner links to its own Q-omics profile.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF3IP1→partner) and Y-score (partner→TRAF3IP1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	MSGN1 →	+0.082	+3.345	<.001	.007	3	1
LARGE_INTESTINE	ADAM7 →	+0.004	+3.345	<.001	.007	3	1
BLOOD_Lymphoma	WFDC8 →	+0.018	+4.867	<.001	.009	3	1
LUNG_SCLC	CD300LD →	+0.019	+5.029	<.001	.006	3	1
LUNG_NSCLC_LUAD	OR4D6 →	+0.742	+5.662	<.001	.002	3	1
LUNG_NSCLC_LUAD	RNASE9 →	+0.015	+4.887	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

Exploration

TRAF3IP1 survival (RNA) · tumor vs normal (RNA) · all TRAF3IP1 data types