TRAF3

Across TCGA patient cohorts, TRAF3 RNA expression is significantly associated with the go_rna of many other GO terms, with 7,166 significant associations in total. PRAD shows the largest number of these associations.

The most reproducible TRAF3-associated GO terms across cancer lineages are Phosphatidylinositol metabolic process, Sex-chromosome dosage compensation, and Negative regulation of gene expression, epigenetic. Each is linked with TRAF3 in more than 31 cancer types. Because this analysis shows association rather than direction, both TRAF3-to-partner and partner-to-TRAF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Phosphatidylinositol metabolic process grouped by TRAF3-low versus TRAF3-high in DLBC.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF3→partner) and Y-score (partner→TRAF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
DLBC	Phosphatidylinositol metabolic process →	+0.043	+0.800	.001	<.001	3	32
DLBC	Sex-chromosome dosage compensation →	+0.076	+0.972	<.001	<.001	3	32
DLBC	Negative regulation of gene expression, epigenetic →	+0.076	+1.034	<.001	<.001	3	31
UCS	Microtubule polymerization →	+0.041	+0.696	.003	.002	2	32
DLBC	Phosphatidylinositol phosphate biosynthetic process →	+0.060	+0.742	<.001	<.001	3	31
CHOL	Activation of GTPase activity →	+0.038	+0.963	<.001	<.001	3	31

Each partner links to its Q-omics profile. Showing the 6 strongest of 7,166 associations by consensus.

Phosphatidylinositol metabolic process by TRAF3 expression — DLBC

Explore this box plot interactively →