TRAF3

Across TCGA patient cohorts, TRAF3 mutation is significantly associated with the RNA expression of many other genes, with 1,234 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAF3-associated genes across cancer lineages are HAUS1, SKA1, and CHAF1B. Each is linked with TRAF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF3-to-partner and partner-to-TRAF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, HAUS1 grouped by TRAF3-low versus TRAF3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF3→partner) and Y-score (partner→TRAF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	HAUS1 →	+0.598	+2.423	<.001	.001	3	2
UCEC	SKA1 →	+0.647	+1.936	<.001	.003	3	2
UCEC	CHAF1B →	+0.560	+2.016	.001	.005	3	2
UCEC	CENPN →	+0.673	+1.947	<.001	.003	3	2
UCEC	ZNF232 →	+0.571	+3.823	<.001	<.001	3	2
UCEC	ELP5 →	+0.426	+1.958	<.001	.003	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,234 associations by consensus.

HAUS1 by TRAF3 expression — UCEC

Explore this box plot interactively →