TRAF3

Across TCGA cell cohorts, TRAF3 mutation is significantly associated with the RNA expression of many other genes, with 16 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRAF3-associated genes across cancer lineages are LRTM1, FGF21, and PROX1. Each is linked with TRAF3 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF3-to-partner and partner-to-TRAF3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, LRTM1 grouped by TRAF3-low versus TRAF3-high in BLOOD_Myeloma.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF3→partner) and Y-score (partner→TRAF3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Myeloma	LRTM1 →	+0.016	+3.169	<.001	.004	3	1
BLOOD_Leukemia	FGF21 →	+0.147	+2.542	.009	.007	3	1
BLOOD_Leukemia	PROX1 →	+0.549	+3.459	<.001	.003	3	1
BLOOD_Leukemia	ADRA1A →	+0.167	+2.799	<.001	.005	3	1
BLOOD_Leukemia	FIGLA →	+0.012	+3.762	<.001	.007	3	1
BLOOD_Leukemia	TEX48 →	+0.026	+3.153	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 16 associations by consensus.

LRTM1 by TRAF3 expression — BLOOD_Myeloma

Explore this box plot interactively →