TRAF1

Across TCGA pan-cancer cohorts, TRAF1 mass-spec protein is linked to patient survival in 5 of 34 cancer types, making it a survival-associated TRAF1 data layer compared with 28 for mass-spec protein and 4 for mutation status.

The strongest signal is observed in pancreatic ductal adenocarcinoma (PDAC), where higher TRAF1 mass-spec protein is associated with better overall survival. In most high-consensus cancer types, elevated TRAF1 expression acts as an unfavorable survival marker, although some lineages such as PDAC and CCRCC show a favorable association.

PDAC, LSCC, and CCRCC are the cancer types where TRAF1 mass-spec protein most reproducibly stratifies survival.

mass-spec protein survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
PDAC	OS	Tertile	All	0.704	0.372	<.001	57	view →
LSCC	DFS	Tertile	II,III,IV	0.481	0.946	.001	22	view →
CCRCC	DFS	Quartile	II,III,IV	0.732	0.322	.007	15	view →
GBM	OS	Median	All	0.387	0.695	.001	15	view →
LUAD	DFS	Median	All	0.731	0.416	.008	14	view →

Pink = unfavorable, green = favorable. Showing the 5 strongest of 5 lineages.

TRAF1–PDAC (OS)

Open the PDAC breakdown →