TRAF1

Across TCGA patient cohorts, TRAF1 mutation is significantly associated with the total protein of many other genes, with 8 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAF1-associated genes across cancer lineages are Gab2, MEK1, and MSH2. Each is linked with TRAF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF1-to-partner and partner-to-TRAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Gab2 grouped by TRAF1-low versus TRAF1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF1→partner) and Y-score (partner→TRAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Gab2 →	+0.390	+2.584	.019	.011	3	1
UCEC	MEK1 →	+0.391	+2.584	.021	.011	3	1
UCEC	MSH2 →	-0.359	-3.143	<.001	.018	3	1
UCEC	Notch1 →	+0.234	+2.331	<.001	.019	3	1
UCEC	p21 →	+0.229	+2.820	.010	.035	3	1
UCEC	p62 Lck ligand →	+0.304	+2.584	.045	.011	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 8 associations by consensus.

Gab2 by TRAF1 expression — UCEC

Explore this box plot interactively →