TRAF1

Across TCGA cell cohorts, TRAF1 RNA expression is significantly associated with the go_rna of many other GO terms, with 4,045 significant associations in total. CNS shows the largest number of these associations.

The most reproducible TRAF1-associated GO terms across cancer lineages are PML body organization, Regulation of response to cytokine stimulus, and Regulation of cytokine-mediated signaling pathway. Each is linked with TRAF1 in more than 12 cancer types. Because this analysis shows association rather than direction, both TRAF1-to-partner and partner-to-TRAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PML body organization grouped by TRAF1-low versus TRAF1-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF1→partner) and Y-score (partner→TRAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	PML body organization →	+0.210	+1.958	.003	.001	3	13
UPPER_AERODIGESTIVE_TRACT	Regulation of response to cytokine stimulus →	+0.067	+0.716	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Regulation of cytokine-mediated signaling pathway →	+0.092	+0.883	<.001	.001	3	12
UPPER_AERODIGESTIVE_TRACT	Antigen processing and presentation of endogenous antigen →	+0.243	+0.966	<.001	.002	3	12
UPPER_AERODIGESTIVE_TRACT	Antigen processing and presentation of endogenous peptide antigen via MHC class I →	+0.238	+1.291	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Antigen processing and presentation of endogenous peptide antigen →	+0.191	+0.865	.001	.001	3	12

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,045 associations by consensus.

PML body organization by TRAF1 expression — LIVER

Explore this box plot interactively →