TRAF1

Across TCGA cell cohorts, TRAF1 mutation is significantly associated with the RNA expression of many other genes, with 28 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible TRAF1-associated genes across cancer lineages are GALP, PSKH2, and PTGDR. Each is linked with TRAF1 in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAF1-to-partner and partner-to-TRAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GALP grouped by TRAF1-low versus TRAF1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF1→partner) and Y-score (partner→TRAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	GALP →	+0.014	+4.415	<.001	.007	3	2
SKIN	PSKH2 →	+0.022	+5.217	<.001	<.001	3	1
SKIN	PTGDR →	+0.018	+4.930	<.001	.001	3	1
SKIN	SHISA6 →	+0.028	+5.217	<.001	<.001	3	1
SKIN	PRAMEF33 →	+0.012	+4.415	<.001	.007	3	1
SKIN	TRPC5 →	+0.013	+4.684	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 28 associations by consensus.

GALP by TRAF1 expression — SKIN

Explore this box plot interactively →