TRAF1

Across TCGA cell cohorts, TRAF1 mutation is significantly associated with the mutation status of many other genes, with 2,930 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible TRAF1-associated genes across cancer lineages are PBX4, FBF1, and RBM12B. Each is linked with TRAF1 in more than 3 cancer types. Because this analysis shows association rather than direction, both TRAF1-to-partner and partner-to-TRAF1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PBX4 grouped by TRAF1-low versus TRAF1-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAF1→partner) and Y-score (partner→TRAF1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	PBX4 →	+5.053	+4.239	.007	.007	1	4
BLOOD_Lymphoma	FBF1 →	+4.014	+4.969	.008	.008	1	4
BLOOD_Lymphoma	RBM12B →	+4.014	+4.969	.008	.008	1	4
BLOOD_Lymphoma	PUM2 →	+4.429	+5.247	.005	.005	1	3
LARGE_INTESTINE	NADK →	+4.329	+4.329	.001	.001	1	3
BLOOD_Leukemia	FERMT1 →	+5.050	+4.000	.008	.008	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 2,930 associations by consensus.

PBX4 by TRAF1 expression — SKIN

Explore this box plot interactively →