TRAC

Across TCGA patient cohorts, TRAC mutation is significantly associated with the total protein of many other genes, with 43 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRAC-associated genes across cancer lineages are Notch1, PKC-delta_pS664, and Rad50. Each is linked with TRAC in more than 1 cancer types. Because this analysis shows association rather than direction, both TRAC-to-partner and partner-to-TRAC results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Notch1 grouped by TRAC-low versus TRAC-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRAC→partner) and Y-score (partner→TRAC) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Notch1 →	+0.223	+2.235	<.001	.005	3	2
UCEC	PKC-delta_pS664 →	-0.101	-3.459	.025	.005	3	2
UCEC	Rad50 →	-0.220	-2.169	.015	.003	3	2
UCEC	14-3-3_beta →	-0.091	-2.558	.016	.010	3	1
UCEC	EGFR_pY1068 →	-0.279	-2.169	.002	.003	3	1
UCEC	eIF4G →	+0.321	+3.169	.005	.018	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 43 associations by consensus.

Notch1 by TRAC expression — UCEC

Explore this box plot interactively →