TRA2A

Across TCGA patient cohorts, TRA2A mutation is significantly associated with the total protein of many other genes, with 33 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible TRA2A-associated genes across cancer lineages are MEK1, Annexin-1, and Src_pY527. Each is linked with TRA2A in more than 1 cancer types. Because this analysis shows association rather than direction, both TRA2A-to-partner and partner-to-TRA2A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MEK1 grouped by TRA2A-low versus TRA2A-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (TRA2A→partner) and Y-score (partner→TRA2A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MEK1 →	+0.405	+2.807	.003	.003	3	2
UCEC	Annexin-1 →	+0.645	+2.087	.001	.005	3	2
UCEC	Src_pY527 →	-0.520	-2.797	.001	.003	3	2
UCEC	ASNS →	+0.435	+2.000	.001	.030	3	2
UCEC	ATM →	-0.658	-3.571	<.001	.002	3	2
UCEC	Caspase-7-cleavedD198 →	+0.503	+2.479	.027	.010	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 33 associations by consensus.

MEK1 by TRA2A expression — UCEC

Explore this box plot interactively →